Atypical E2Fs inhibit tumor angiogenesis
نویسندگان
چکیده
منابع مشابه
Chk1 and 14‐3‐3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest
The atypical E2Fs, E2F7 and E2F8, act as potent transcriptional repressors of DNA replication genes providing them with the ability to induce a permanent S-phase arrest and suppress tumorigenesis. Surprisingly in human cancer, transcript levels of atypical E2Fs are frequently elevated in proliferating cancer cells, suggesting that the tumor suppressor functions of atypical E2Fs might be inhibit...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2017
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2017.336